Filtered selection coupled with support vector machines generate a functionally relevant prediction model for colorectal cancer.

ABSTRACT:

Purpose

There has been considerable interest in using whole-genome expression profiles for the classification of colorectal cancer (CRC). The selection of important features is a crucial step before training a classifier.

Methods

In this study, we built a model that uses support vector machine (SVM) to classify cancer and normal samples using Affymetrix exon microarray data obtained from 90 samples of 48 patients diagnosed with CRC. From the 22,011 genes, we selected the 20, 30, 50, 100, 200, 300, and 500 genes most relevant to CRC using the minimum-redundancy-maximum-relevance (mRMR) technique. With these gene sets, an SVM model was designed using four different kernel types (linear, polynomial, radial basis function [RBF], and sigmoid).

Results

The best model, which

SUBMITTER: Gabere MN 

PROVIDER: S-EPMC4898422 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature