Genome-wide association analysis and replication of coronary artery disease in South Korea suggests a causal variant common to diverse populations.

ABSTRACT:

Background

Recent genome-wide association (GWA) studies have identified and replicated several genetic loci associated with the risk of development of coronary artery disease (CAD) in samples from populations of Caucasian and Asian descent. However, only chromosome 9p21 has been confirmed as a major susceptibility locus conferring risk for development of CAD across multiple ethnic groups. The authors aimed to find evidence of further similarities and differences in genetic risk of CAD between Korean and other populations.

Methods

The authors performed a GWA study comprising 230 cases and 290 controls from a Korean population typed on 490 032 single nucleotide polymorphisms (SNPs). A total of 3148 SNPs were taken forward for genotyping in a subsequent replication study using

SUBMITTER: Cho EY 

PROVIDER: S-EPMC4898511 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature