Breaking Good: Accounting for Fragility of Genomic Regions in Rearrangement Distance Estimation.

ABSTRACT: Models of evolution by genome rearrangements are prone to two types of flaws: One is to ignore the diversity of susceptibility to breakage across genomic regions, and the other is to suppose that susceptibility values are given. Without necessarily supposing their precise localization, we call "solid" the regions that are improbably broken by rearrangements and "fragile" the regions outside solid ones. We propose a model of evolution by inversions where breakage probabilities vary across fragile regions and over time. It contains as a particular case the uniform breakage model on the nucleotidic sequence, where breakage probabilities are proportional to fragile region lengths. This is very different from the frequently used pseudouniform model where all fragile regions have the same probab

SUBMITTER: Biller P 

PROVIDER: S-EPMC4898800 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature