Altered interoceptive awareness in anorexia nervosa: Effects of meal anticipation, consumption and bodily arousal.

ABSTRACT:

Objective

Impaired interoceptive awareness (IA), the subjective perception of internal body sensations, has been proposed as a vulnerability or maintaining factor in anorexia nervosa (AN). We examined whether IA of heartbeat and breathing sensations was impaired in AN across a range of arousal levels, and whether it was influenced by meal anticipation and consumption.

Method

IA was assessed using randomized, double-blinded, bolus intravenous infusions of isoproterenol, a peripheral beta-adrenergic sympathetic agonist, and saline. Fifteen women with AN and 15 age-, and sex- matched healthy comparisons (HC) were evaluated before and after consumption of a 1,000 Calorie meal. During each infusion participants rated their moment-to-moment intensity of heartbeat and breathing sen

SUBMITTER: Khalsa SS 

PROVIDER: S-EPMC4898968 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature