Copy-number variation of MCL1 predicts overall survival of non-small-cell lung cancer in a Southern Chinese population.

ABSTRACT: BCL2L1 and MCL1 are key anti-apoptotic genes, and critical for cancer progression. The prognostic values of BCL2L1 and MCL1 copy-number variations (CNVs) in non-small-cell lung cancer (NSCLC) remain largely unknown. Somatic CNVs in BCL2L1 and MCL1 genes were tested in tumor tissues from 516 NSCLC patients in southern China; afterward, survival analyses were conducted with overall survival (OS) as outcome. Additionally, the associations between CNVs and mRNA expression levels were explored using data from 986 NSCLC patients in the Cancer Genome Atlas project. It was found that amplifications of BCL2L1 and MCL1 were associated with unfavorable OS of NSCLC, with adjusted hazards ratio of 1.62 (95% confident interval [CI] = 1.10-2.40; P = 0.015) and 1.39 (95% CI = 1.05-1.84; P = 0.020), respec

SUBMITTER: Yin J 

PROVIDER: S-EPMC4898974 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature