Assessing sample representativeness in randomized controlled trials: application to the National Institute of Drug Abuse Clinical Trials Network.

ABSTRACT:

Aims

To compare the characteristics of individuals participating in randomized controlled trials (RCTs) of treatments of substance use disorder (SUD) with individuals receiving treatment in usual care settings, and to provide a summary quantitative measure of differences between characteristics of these two groups of individuals using propensity score methods. Design Analyses using data from RCT samples from the National Institute of Drug Abuse Clinical Trials Network (CTN) and target populations of patients drawn from the Treatment Episodes Data Set-Admissions (TEDS-A). Settings Multiple clinical trial sites and nation-wide usual SUD treatment settings in the United States.

Participants

A total of 3592 individuals from 10 CTN samples and 1 602 226 individuals selected from

SUBMITTER: Susukida R 

PROVIDER: S-EPMC4899104 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature