Peri-gestational risk factors for pediatric brain tumors in Neurofibromatosis Type 1.

ABSTRACT:

Background

Individuals with Neurofibromatosis Type 1 (NF1) are strongly predisposed to developing pediatric brain tumors (PBTs), especially optic pathway gliomas (OPGs). Although developmental factors have been implicated in the origins of PBTs in both human and animal studies, associations between early-life factors and PBTs have not been evaluated in individuals with NF1. Our objective was to evaluate associations between peri-gestational characteristics and PBTs in this population.

Methods

We conducted a cross-sectional study, ascertaining questionnaire and medical record data for 606 individuals<18years old who enrolled in the NF1 Patient Registry Initiative (NPRI) from 6/9/2011-6/29/2015. One hundred eighty-four individuals had reported PBT diagnoses, including 65 who w

SUBMITTER: Johnson KJ 

PROVIDER: S-EPMC4899111 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature