Cell-based tissue engineering strategies used in the clinical repair of articular cartilage.

ABSTRACT: One of the most important issues facing cartilage tissue engineering is the inability to move technologies into the clinic. Despite the multitude of current research in the field, it is known that 90% of new drugs that advance past animal studies fail clinical trials. The objective of this review is to provide readers with an understanding of the scientific details of tissue engineered cartilage products that have demonstrated a certain level of efficacy in humans, so that newer technologies may be developed upon this foundation. Compared to existing treatments, such as microfracture or autologous chondrocyte implantation, a tissue engineered product can potentially provide more consistent clinical results in forming hyaline repair tissue and in filling the entirety of the defect. The vari

SUBMITTER: Huang BJ 

PROVIDER: S-EPMC4899115 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature