Plasma uric acid concentrations and risk of ischaemic stroke in women.

ABSTRACT:

Background and purpose

Elevated plasma uric acid has been inconsistently associated with an increased risk of total stroke; however, data are sparse amongst women. The association between plasma uric acid concentrations and ischaemic stroke amongst women was examined and the effect modification by key cardiovascular risk factors was evaluated.

Methods

A nested case-control design with matching by age, race/ethnicity, smoking status, menopausal status, postmenopausal hormone therapy use, date of blood draw and fasting status was utilized amongst female participants of the Nurses' Health Study who provided blood samples between 1989 and 1990. Plasma uric acid was measured on stored blood samples. The National Survey of Stroke criteria were utilized to confirm 460 incident case

SUBMITTER: Jimenez MC 

PROVIDER: S-EPMC4899277 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature