The tryptophan metabolism enzyme L-kynureninase is a novel inflammatory factor in psoriasis and other inflammatory diseases.

ABSTRACT:

Background

Many human diseases arise from or have pathogenic contributions from a dysregulated immune response. One pathway with immunomodulatory ability is the tryptophan metabolism pathway, which promotes immune suppression through the enzyme indoleamine 2,3-dioxygenase (IDO) and subsequent production of kynurenine. However, in patients with chronic inflammatory skin disease, such as psoriasis and atopic dermatitis (AD), another tryptophan metabolism enzyme downstream of IDO, L-kynureninase (KYNU), is heavily upregulated. The role of KYNU has not been explored in patients with these skin diseases or in general human immunology.

Objective

We sought to explore the expression and potential immunologic function of the tryptophan metabolism enzyme KYNU in inflammatory skin dise

SUBMITTER: Harden JL 

PROVIDER: S-EPMC4899291 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature