Genomic insights into the ESBL and MCR-1-producing ST648 Escherichiacoli with multi-drug resistance.

ABSTRACT: Polymyxin acts as an ultimate line of refuge against the severe infections by multidrug-resistant Gram-negative pathogens. This conventional idea is challenged dramatically by the recent discovery of mobile colistin resistance gene (mcr-1) is prevalent in food animals and human beings worldwide. More importantly, the mcr-1 gene was found to be co-localized with other antibiotic resistance genes, raising the possibility that super-bugs with pan-drug resistance are emerging. However, little is reported on the genomes of the mcr-1-positive bacterial host reservoirs. Here we report genome sequencing of three human isolates of the mcr-1-positive Escherichia coli (E15004, E15015 and E15017) and define general features through analyse

SUBMITTER: Zhang H 

PROVIDER: S-EPMC4899488 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature