Comparative Genomics of Herpesviridae Family to Look for Potential Signatures of Human Infecting Strains.

ABSTRACT: Herpesviridae family is one of the significant viral families which comprises major pathogens of a wide range of hosts. This family includes at least eight species of viruses which are known to infect humans. This family has evolved 180-220 million years ago and the present study highlights that it is still evolving and more genes can be added to the repertoire of this family. In addition, its core-genome includes important viral proteins including glycoprotein B and helicase. Most of the infections caused by human herpesviruses have no definitive cure; thus, search for new therapeutic strategies is necessary. The present study finds core-genome of human herpesviruses that differs from that of Herpesviridae family and nonhuman herpes strains of this family and might be a putative target fo

SUBMITTER: Sharma V 

PROVIDER: S-EPMC4899598 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature