Optimal Trend Tests for Genetic Association Studies of Heterogeneous Diseases.

ABSTRACT: The Cochran-Armitage trend test is a standard procedure in genetic association studies. It is a directed test with high power to detect genetic effects that follow the gene-dosage model. In this paper, the author proposes optimal trend tests for genetic association studies of heterogeneous diseases. Monte-Carlo simulations show that the power gain of the optimal trend tests over the conventional Cochran-Armitage trend test is striking when the genetic effects are heterogeneous. The easy-to-use R 3.1.2 software (R Foundation for Statistical Computing, Vienna, Austria) code is provided. The optimal trend tests are recommended for routine use.

SUBMITTER: Lee WC 

PROVIDER: S-EPMC4899796 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature