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Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C.

ABSTRACT: Persistently activated Stat3 is found in many different cancers, including approximately 60% of breast tumors. Here, we demonstrate that a constitutively activated Stat3 transforms immortalized human mammary epithelial cells and that this oncogenic event requires the activity of matrix metalloproteinase-9 (MMP-9). By immunohistochemical analysis, we observe a positive correlation between strong MMP-9 expression and tyrosine phosphorylated Stat3 in primary breast cancer specimens. These results demonstrate a relationship between activated Stat3 and MMP-9 in breast oncogenesis.

SUBMITTER: Dechow TN

PROVIDER: S-EPMC489981 | biostudies-literature | 2004 Jul

REPOSITORIES: biostudies-literature

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Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C.

Dechow Tobias N TN Pedranzini Laura L Leitch Andrea A Leslie Kenneth K Gerald William L WL Linkov Irina I Bromberg Jacqueline F JF

Proceedings of the National Academy of Sciences of the United States of America 20040712 29

Persistently activated Stat3 is found in many different cancers, including approximately 60% of breast tumors. Here, we demonstrate that a constitutively activated Stat3 transforms immortalized human mammary epithelial cells and that this oncogenic event requires the activity of matrix metalloproteinase-9 (MMP-9). By immunohistochemical analysis, we observe a positive correlation between strong MMP-9 expression and tyrosine phosphorylated Stat3 in primary breast cancer specimens. These results d ...[more]

PMID: 15249664

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