Asymmetric dimethylarginine, related arginine derivatives, and incident atrial fibrillation.

ABSTRACT:

Background

Oxidative stress plays an important role in the development of atrial fibrillation (AF). Arginine derivatives including asymmetric dimethylarginine (ADMA) are central to nitric oxide metabolism and nitrosative stress. Whether blood concentrations of arginine derivatives are related to incidence of AF is uncertain.

Methods and results

In 3,310 individuals (mean age 58 ± 10 years, 54% women) from the community-based Framingham Study, we prospectively examined the relations of circulating levels of ADMA, l-arginine, symmetric dimethylarginine (SDMA), and the ratio of l-arginine/ADMA to incidence of AF using proportional hazards regression models. Over a median follow-up time of 10 years, 247 AF cases occurred. Using age- and sex-adjusted regression models, ADMA was a

SUBMITTER: Schnabel RB 

PROVIDER: S-EPMC4899814 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature