IL-6 stimulates a concentration-dependent increase in MCP-1 in immortalised human brain endothelial cells.

ABSTRACT: Systemic inflammation is associated with neurodegeneration, with elevated interleukin-6 (IL-6) in particular being correlated with an increased risk of dementia. The brain endothelial cells of the blood brain barrier (BBB) serve as the interface between the systemic circulation and the brain microenvironment and are therefore likely to be a key player in the development of neuropathology associated with systemic inflammation. Endothelial cells are known to require soluble IL-6 receptor (sIL-6R) in order to respond to IL-6, but studies in rat models have shown that this is not the case for brain endothelial cells and studies conducted in human cells are limited. Here we report for the first time that the human cerebral microvascular cell line, hCMVEC, uses the classical mIL-6R signalling pa

SUBMITTER: Choi JM 

PROVIDER: S-EPMC4900293 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature