The Drosophila ETV5 Homologue Ets96B: Molecular Link between Obesity and Bipolar Disorder.

ABSTRACT: Several reports suggest obesity and bipolar disorder (BD) share some physiological and behavioural similarities. For instance, obese individuals are more impulsive and have heightened reward responsiveness, phenotypes associated with BD, while bipolar patients become obese at a higher rate and earlier age than people without BD; however, the molecular mechanisms of such an association remain obscure. Here we demonstrate, using whole transcriptome analysis, that Drosophila Ets96B, homologue of obesity-linked gene ETV5, regulates cellular systems associated with obesity and BD. Consistent with a role in obesity and BD, loss of nervous system Ets96B during development increases triacylglyceride concentration, while inducing a heightened startle-response, as well as increasing hyperactivity an

SUBMITTER: Williams MJ 

PROVIDER: S-EPMC4900636 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature