Callyspongiolide, a cytotoxic macrolide from the marine sponge Callyspongia sp.

ABSTRACT: A novel macrolide, callyspongiolide, whose structure was determined by comprehensive analysis of the NMR and HRMS spectra, was isolated from the marine sponge Callyspongia sp. collected in Indonesia. The compound features a carbamate-substituted 14-membered macrocyclic lactone ring with a conjugated structurally unprecedented diene-ynic side chain terminating at a brominated benzene ring. Callyspongiolide showed strong cytotoxicity against human Jurkat J16 T and Ramos B lymphocytes.

SUBMITTER: Pham CD 

PROVIDER: S-EPMC4900817 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature