Chronic Interactions Between Carotid Baroreceptors and Chemoreceptors in Obesity Hypertension.

ABSTRACT: Carotid bodies play a critical role in protecting against hypoxemia, and their activation increases sympathetic activity, arterial pressure, and ventilation, responses opposed by acute stimulation of the baroreflex. Although chemoreceptor hypersensitivity is associated with sympathetically mediated hypertension, the mechanisms involved and their significance in the pathogenesis of hypertension remain unclear. We investigated the chronic interactions of these reflexes in dogs with sympathetically mediated, obesity-induced hypertension based on the hypothesis that hypoxemia and tonic activation of carotid chemoreceptors may be associated with obesity. After 5 weeks on a high-fat diet, the animals experienced a 35% to 40% weight gain and increases in arterial pressure from 106±3 to 123±3 mm H

SUBMITTER: Lohmeier TE 

PROVIDER: S-EPMC4900898 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature