Zbtb20 modulates the sequential generation of neuronal layers in developing cortex.

ABSTRACT:

Background

During corticogenesis, genetic programs encoded in progenitor cells at different developmental stages and inherited in postmitotic neurons specify distinct layer and area identities. Transcription factor Zbtb20 has been shown to play a role for hippocampal development but whether it is implicated in mammalian neocortical morphogenesis remains unknown.

Results

Here, we report that during embyogenesis transcription factor Zbtb20 has a dynamic spatio-temporal expression pattern in mitotic cortical progenitors through which it modulates the sequential generation of cortical neuronal layer identities. Zbtb20 knock out mice exhibited enhanced populations of early born L6-L4 neuronal subtypes and a dramatic reduction of the late born L3/L2 neurons. This defect was due to

SUBMITTER: Tonchev AB 

PROVIDER: S-EPMC4901408 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature