Bivariate genome-wide association study identifies novel pleiotropic loci for lipids and inflammation.

ABSTRACT:

Background

Genome-wide association studies (GWAS) have identified multiple genetic loci for C-reactive protein (CRP) and lipids, of which some overlap. We aimed to identify genetic pleiotropy among CRP and lipids in order to better understand the shared biology of chronic inflammation and lipid metabolism.

Results

In a bivariate GWAS, we combined summary statistics of published GWAS on CRP (n = 66,185) and lipids, including LDL-cholesterol, HDL-cholesterol, triglycerides, and total cholesterol (n = 100,184), using an empirical weighted linear-combined test statistic. We sought replication for novel CRP associations in an independent sample of 17,743 genotyped individuals, and performed in silico replication of novel lipid variants in 93,982 individuals. Fifty potentially ple

SUBMITTER: Ligthart S 

PROVIDER: S-EPMC4901478 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature