Halofuginone suppresses growth of human uterine leiomyoma cells in a mouse xenograft model.

ABSTRACT:

Study question

Does halofuginone (HF) inhibit the growth of human uterine leiomyoma cells in a mouse xenograft model?

Summary answer

HF suppresses the growth of human uterine leiomyoma cells in a mouse xenograft model through inhibiting cell proliferation and inducing apoptosis.

What is known already

Uterine leiomyomas are the most common benign tumors of the female reproductive tract. HF can suppress the growth of human uterine leiomyoma cells in vitro. The mouse xenograft model reflects the characteristics of human leiomyomas.

Study design, size, duration

Primary leiomyoma smooth muscle cells from eight patients were xenografted under the renal capsule of adult, ovariectomized NOD-scid IL2Rγ(null) mice (NSG). Mice were treated with two different doses of HF o

SUBMITTER: Koohestani F 

PROVIDER: S-EPMC4901881 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature