Self-collected dried blood spots as a tool for measuring ovarian reserve in young female cancer survivors.

ABSTRACT:

Study question

Are female young cancer survivors (YCS) able to self-collect high-quality dried blood spots (DBSs) at home to provide biospecimens for studying ovarian reserve?

Summary answer

YCS can self-collect high-quality DBS specimens in non-clinical settings, and anti-Mullerian hormone (AMH) levels can be assayed in such specimens.

What is known already

Large-scale biosample collection is a barrier to studying ovarian reserve in YCS. DBS collected by research personnel has high acceptability. AMH levels measured in DBS are highly correlated with those measured by serum-based methods.

Study design, size, duration

In a prospective cohort study, YCS were recruited to self-collect DBS samples. AMH levels were assayed in 112 samples.

Participants/materials,

SUBMITTER: Roberts SC 

PROVIDER: S-EPMC4901885 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature