Asymmetric α-amination of 3-substituted oxindoles using chiral bifunctional phosphine catalysts.

ABSTRACT: A highly enantioselective α-amination of 3-substituted oxindoles with azodicarboxylates catalyzed by amino acids-derived chiral phosphine catalysts is reported. The corresponding products containing a tetrasubstituted carbon center attached to a nitrogen atom at the C-3 position of the oxindole were obtained in high yields and with up to 98% ee.

SUBMITTER: Jin QW 

PROVIDER: S-EPMC4902028 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature