Self-Assembly of Disorazole C₁ through a One-Pot Alkyne Metathesis Homodimerization Strategy.

ABSTRACT: Alkyne metathesis is increasingly explored as a reliable method to close macrocyclic rings, but there are no prior examples of an alkyne-metathesis-based homodimerization approach to natural products. In this approach to the cytotoxic C₂ -symmetric marine-derived bis(lactone) disorazole C₁, a highly convergent, modular strategy is employed featuring cyclization through an ambitious one-pot alkyne cross-metathesis/ring-closing metathesis self-assembly process.

SUBMITTER: Ralston KJ 

PROVIDER: S-EPMC4902119 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature