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Methane as a Selectivity Booster in the Arc-Discharge Synthesis of Endohedral Fullerenes: Selective Synthesis of the Single-Molecule Magnet Dy2TiC@C80 and Its Congener Dy2TiC2@C80.

ABSTRACT: The use of methane as a reactive gas dramatically increases the selectivity of the arc-discharge synthesis of M-Ti-carbide clusterfullerenes (M=Y, Nd, Gd, Dy, Er, Lu). Optimization of the process parameters allows the synthesis of Dy2TiC@C80-I and its facile isolation in a single chromatographic step. A new type of cluster with an endohedral acetylide unit, M2TiC2@C80, is discovered along with the second isomer of M2TiC@C80. Dy2TiC@C80-(I,II) and Dy2TiC2@C80-I are shown to be single-molecule magnets (SMM), but the presence of the second carbon atom in the cluster Dy2TiC2@C80 leads to substantially poorer SMM properties.

SUBMITTER: Junghans K

PROVIDER: S-EPMC4902133 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature

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Publications

Methane as a Selectivity Booster in the Arc-Discharge Synthesis of Endohedral Fullerenes: Selective Synthesis of the Single-Molecule Magnet Dy2TiC@C80 and Its Congener Dy2TiC2@C80.

Junghans Katrin K Schlesier Christin C Kostanyan Aram A Samoylova Nataliya A NA Deng Qingming Q Rosenkranz Marco M Schiemenz Sandra S Westerström Rasmus R Greber Thomas T Büchner Bernd B Popov Alexey A AA

Angewandte Chemie (International ed. in English) 20150909 45

The use of methane as a reactive gas dramatically increases the selectivity of the arc-discharge synthesis of M-Ti-carbide clusterfullerenes (M=Y, Nd, Gd, Dy, Er, Lu). Optimization of the process parameters allows the synthesis of Dy2TiC@C80-I and its facile isolation in a single chromatographic step. A new type of cluster with an endohedral acetylide unit, M2TiC2@C80, is discovered along with the second isomer of M2TiC@C80. Dy2TiC@C80-(I,II) and Dy2TiC2@C80-I are shown to be single-molecule mag ...[more]

PMID: 26350440

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Project description:Low back pain is the most common health problem with a prevalence of over 80% worldwide and an estimated annual cost of $100 billion in the United States. Intervertebral disc degeneration accounts for a major cause of low back pain. However, there is still a lack of safe and effective treatment to tackle this devastating condition. In this study, we synthesized four functionalized trimetallic nitride endohedral metallofullerenes (carboxyl-f-Sc3N@C80, carboxyl-f-Gd3N@C80, amino-f-Sc3N@C80, and amino-f-Gd3N@C80) and characterized them with X-ray photoelectron spectroscopy, matrix-assisted laser desorption/ionization-time of flight mass spectrometry, and UV-vis. Via electron paramagnetic resonance, all four metallofullerene derivatives possessed dose-dependent radical scavenging capabilities (hydroxyl radicals and superoxide anions), with the most promising radical scavenging properties shown in the amine functionalized C80 metallofullerenes. Both amino-f-Sc3N@C80 and amino-f-Gd3N@C80 at 1 μM significantly reduced lipopolysaccharide induced reactive oxygen species production and mRNA expressions of pro-inflammatory mediators (inos, tnf-α, il-1, and cox-2) in macrophages without apparent cytotoxicity through regulating activity of p38 MAPK, p65, and nuclear translocation of NF-κB. Furthermore, in an established mouse model of lumbar radiculopathy, amino-f-Sc3N@C80 and amino-f-Gd3N@C80 effectively alleviated ipsilateral mechanical hyperalgesia for up to 2 weeks. In dorsal root ganglia explant culture, we also showed that amino-f-Sc3N@C80 and amino-f-Gd3N@C80 ameliorated TNF-α elicited neuroinflammation. In summary, we presented results for a potent radical scavenging, anti-inflammatory and analgesic nanoparticle, amino-functionalized eighty-carbon metallofullerenes in vitro and in vivo. Our study provides important assets for developing pleiotropic treatment strategies to tackle the inflammation, a significant pathological hallmark in the intervertebral disc degeneration and associated pain.

Dataset Information

Methane as a Selectivity Booster in the Arc-Discharge Synthesis of Endohedral Fullerenes: Selective Synthesis of the Single-Molecule Magnet Dy2TiC@C80 and Its Congener Dy2TiC2@C80.

Publications

Methane as a Selectivity Booster in the Arc-Discharge Synthesis of Endohedral Fullerenes: Selective Synthesis of the Single-Molecule Magnet Dy2TiC@C80 and Its Congener Dy2TiC2@C80.

Similar Datasets

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