Association of modeled long-term personal exposure to ultrafine particles with inflammatory and coagulation biomarkers.

ABSTRACT:

Background

Long-term exposure to fine particulate matter has been linked to cardiovascular disease and systemic inflammatory responses; however, evidence is limited regarding the effects of long-term exposure to ultrafine particulate matter (UFP, <100nm). We used a cross-sectional study design to examine the association of long-term exposure to near-highway UFP with measures of systemic inflammation and coagulation.

Methods

We analyzed blood samples from 408 individuals aged 40-91years living in three near-highway and three urban background areas in and near Boston, Massachusetts. We conducted mobile monitoring of particle number concentration (PNC) in each area, and used the data to develop and validate highly resolved spatiotemporal (hourly, 20m) PNC regression models. The

SUBMITTER: Lane KJ 

PROVIDER: S-EPMC4902720 | biostudies-literature | 2016 Jul-Aug

REPOSITORIES: biostudies-literature