UBC9-Mediated Sumoylation Favorably Impacts Cardiac Function in Compromised Hearts.

ABSTRACT:

Rationale

SUMOylation plays an important role in cardiac function and can be protective against cardiac stress. Recent studies show that SUMOylation is an integral part of the ubiquitin proteasome system, and expression of the small ubiquitin-like modifier (SUMO) E2 enzyme UBC9 improves cardiac protein quality control. However, the precise role of SUMOylation on other protein degradation pathways, particularly autophagy, remains undefined in the heart.

Objective

To determine whether SUMOylation affects cardiac autophagy and whether this effect is protective in a mouse model of proteotoxic cardiac stress.

Methods and results

We modulated expression of UBC9, a SUMO E2 ligase, using gain- and loss-of-function in neonatal rat ventricular cardiomyocytes. UBC9 expression se

SUBMITTER: Gupta MK 

PROVIDER: S-EPMC4902739 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature