Identification of novel direct targets of Drosophila Sine oculis and Eyes absent by integration of genome-wide data sets.

ABSTRACT: Drosophila eye development is a complex process that involves many transcription factors (TFs) and interactions with their cofactors and targets. The TF Sine oculis (So) and its cofactor Eyes absent (Eya) are highly conserved and are both necessary and sufficient for eye development. Despite their many important roles during development, the direct targets of So are still largely unknown. Therefore the So-dependent regulatory network governing eye determination and differentiation is poorly understood. In this study, we intersected gene expression profiles of so or eya mutant eye tissue prepared from three different developmental stages and identified 1731 differentially expressed genes across the Drosophila genome. A combination of co-expression analyses and motif discovery identified a s

SUBMITTER: Jin M 

PROVIDER: S-EPMC4902760 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature