Comprehensive promoter level expression quantitative trait loci analysis of the human frontal lobe.

ABSTRACT:

Background

Expression quantitative trait loci (eQTL) analysis is a powerful method to detect correlations between gene expression and genomic variants and is widely used to interpret the biological mechanism underlying identified genome wide association studies (GWAS) risk loci. Numerous eQTL studies have been performed on different cell types and tissues of which the majority has been based on microarray technology.

Methods

We present here an eQTL analysis based on cap analysis gene expression sequencing (CAGEseq) data created from human postmortem frontal lobe tissue combined with genotypes obtained through genotyping arrays, exome sequencing, and CAGEseq. Using CAGEseq as an expression profiling technique combined with these different genotyping techniques allows measurem

SUBMITTER: Blauwendraat C 

PROVIDER: S-EPMC4903003 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature