Exploring Transcription Factors-microRNAs Co-regulation Networks in Schizophrenia.

ABSTRACT:

Background

Transcriptional factors (TFs) and microRNAs (miRNAs) have been recognized as 2 classes of principal gene regulators that may be responsible for genome coexpression changes observed in schizophrenia (SZ).

Methods

This study aims to (1) identify differentially coexpressed genes (DCGs) in 3 mRNA expression microarray datasets; (2) explore potential interactions among the DCGs, and differentially expressed miRNAs identified in our dataset composed of early-onset SZ patients and healthy controls; (3) validate expression levels of some key transcripts; and (4) explore the druggability of DCGs using the curated database.

Results

We detected a differential coexpression network associated with SZ and found that 9 out of the 12 regulators were replicated in either of

SUBMITTER: Xu Y 

PROVIDER: S-EPMC4903044 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature