Polygenic Risk of Schizophrenia and Cognition in a Population-Based Survey of Older Adults.

ABSTRACT: Cognitive impairment is a common feature of the major psychotic disorders, with deficits often present in at risk individuals and unaffected first-degree relatives. Previous studies have suggested that polygenic risk scores (PRS) for schizophrenia (SCZ) are associated with cognitive deficits, but there has been little examination of this association in longitudinal datasets, or comparison with other disorders. We used mixed models to study the association between PRS for 4 adult onset psychiatric disorders with cross-sectional cognitive performance and longitudinal cognitive decline in 8616 older adults from the Health and Retirement Study (HRS), followed for an average of 10 years. PRS were computed for SCZ, bipolar disorder (BD), Major Depressive Disorder (MDD), and Alzheimer's disease (

SUBMITTER: Liebers DT 

PROVIDER: S-EPMC4903061 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature