Isolation and characterization of circulating lymphatic endothelial colony forming cells.

ABSTRACT:

Rationale

The identification of circulating endothelial progenitor cells has led to speculation regarding their origin as well as their contribution to neovascular development. Two distinct types of endothelium make up the blood and lymphatic vessel system. However, it has yet to be determined whether there are distinct lymphatic-specific circulating endothelial progenitor cells.

Objective

This study aims to isolate and characterize the cellular properties and global gene expression of lymphatic-specific endothelial progenitor cells.

Methods and results

We isolated circulating endothelial colony forming cells (ECFCs) from whole peripheral blood. These cells are endothelial in nature, as defined by their expression of endothelial markers and their ability to undergo ca

SUBMITTER: DiMaio TA 

PROVIDER: S-EPMC4903174 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature