Spatially-constrained probability distribution model of incoherent motion (SPIM) for abdominal diffusion-weighted MRI.

ABSTRACT: Quantitative diffusion-weighted MR imaging (DW-MRI) of the body enables characterization of the tissue microenvironment by measuring variations in the mobility of water molecules. The diffusion signal decay model parameters are increasingly used to evaluate various diseases of abdominal organs such as the liver and spleen. However, previous signal decay models (i.e., mono-exponential, bi-exponential intra-voxel incoherent motion (IVIM) and stretched exponential models) only provide insight into the average of the distribution of the signal decay rather than explicitly describe the entire range of diffusion scales. In this work, we propose a probability distribution model of incoherent motion that uses a mixture of Gamma distributions to fully characterize the multi-scale nature of diffusio

SUBMITTER: Kurugol S 

PROVIDER: S-EPMC4903917 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature