Reduced GABA neuron density in auditory cerebral cortex of subjects with major depressive disorder.

ABSTRACT: Although major depressive disorder (MDD) and schizophrenia (SZ) are closely associated with disrupted functions in frontal and limbic areas of cerebral cortex, cellular pathology has also been found in other brain areas, including primary sensory cortex. Auditory cortex is of particular interest, given the prominence of auditory hallucinations in SZ, and sensory deficits in MDD. We used stereological sampling methods in auditory cortex to look for cellular differences between MDD, SZ and non-psychiatric subjects. Additionally, as all of our MDD subjects died of suicide, we evaluated the association of suicide with our measurements by selecting a SZ sample that was divided between suicide and non-suicide subjects. Measurements were done in primary auditory cortex (area A1) and auditory asso

SUBMITTER: Smiley JF 

PROVIDER: S-EPMC4903945 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature