Impact of metformin on clinical outcomes among men with prostate cancer: a systematic review and meta-analysis.

ABSTRACT:

Background

Conflicting evidence exists regarding the beneficial effects of metformin in prostate cancer. To determine the association between metformin and clinical outcomes in prostate cancer using systematic review and meta-analysis.

Methods

Original articles published in English until third week of July, 2014 were searched in electronic databases (Medline-Ovid, Scopus, The Cochrane Library, Web of Science, ProQuest) for studies on metformin use in prostate cancer. The clinical outcomes assessed were: development of biochemical recurrence, metastases or castration-resistant metastatic cancer, all-cause and prostate cancer-specific mortality. Meta-analysis was performed to calculate the pooled hazard ratio (pHR) and their 95% confidence interval (95% CI). Heterogeneity betw

SUBMITTER: Raval AD 

PROVIDER: S-EPMC4904224 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature