Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates.

ABSTRACT: The foreign body response is an immune-mediated reaction that can lead to the failure of implanted medical devices and discomfort for the recipient. There is a critical need for biomaterials that overcome this key challenge in the development of medical devices. Here we use a combinatorial approach for covalent chemical modification to generate a large library of variants of one of the most widely used hydrogel biomaterials, alginate. We evaluated the materials in vivo and identified three triazole-containing analogs that substantially reduce foreign body reactions in both rodents and, for at least 6 months, in non-human primates. The distribution of the triazole modification creates a unique hydrogel surface that inhibits recognition by macrophages and fibrous deposition. In addition to t

SUBMITTER: Vegas AJ 

PROVIDER: S-EPMC4904301 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature