Absence of deficits in social behaviors and ultrasonic vocalizations in later generations of mice lacking neuroligin4.

ABSTRACT: Mutations in NLGN4X have been identified in individuals with autism spectrum disorders and other neurodevelopmental disorders. A previous study reported that adult male mice lacking neuroligin4 (Nlgn4) displayed social approach deficits in the three-chambered test, altered aggressive behaviors and reduced ultrasonic vocalizations. To replicate and extend these findings, independent comprehensive analyses of autism-relevant behavioral phenotypes were conducted in later generations of the same line of Nlgn4 mutant mice at the National Institute of Mental Health in Bethesda, MD, USA and at the Institut Pasteur in Paris, France. Adult social approach was normal in all three genotypes of Nlgn4 mice tested at both sites. Reciprocal social interactions in juveniles were similarly normal across ge

SUBMITTER: Ey E 

PROVIDER: S-EPMC4904774 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature