A systematic review of serum autoantibodies as biomarkers for pancreatic cancer detection.

ABSTRACT: Pancreatic cancer is a leading cause of cancer-related deaths in the western world. Patients with pancreatic cancer have poor prognosis, partly due to difficulties in detecting it at early stages. While different markers have been associated with pancreatic cancer, many of them show suboptimal sensitivity and specificity. Serum autoantibodies against tumor-associated antigens have recently emerged as early stage biomarkers for different types of cancers. Given the urgent need for early and reliable biomarkers for pancreatic cancer, we undertook a systematic review of the published literature to identify primary articles that evaluated serum autoantibodies in pancreatic cancer detection by searching PubMed and ISI Web of Knowledge. Two reviewers extracted data on study characteristics and r

SUBMITTER: Dumstrei K 

PROVIDER: S-EPMC4905464 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature