Multivariate Analysis of Genotype-Phenotype Association.

ABSTRACT: With the advent of modern imaging and measurement technology, complex phenotypes are increasingly represented by large numbers of measurements, which may not bear biological meaning one by one. For such multivariate phenotypes, studying the pairwise associations between all measurements and all alleles is highly inefficient and prevents insight into the genetic pattern underlying the observed phenotypes. We present a new method for identifying patterns of allelic variation (genetic latent variables) that are maximally associated-in terms of effect size-with patterns of phenotypic variation (phenotypic latent variables). This multivariate genotype-phenotype mapping (MGP) separates phenotypic features under strong genetic control from less genetically determined features and thus permits an

SUBMITTER: Mitteroecker P 

PROVIDER: S-EPMC4905550 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature