Tanezumab for Patients with Osteoarthritis of the Knee: A Meta-Analysis.

ABSTRACT:

Objective

Tanezumab is a new therapeutic intervention for patients with osteoarthritis (OA) of the knee. We performed the present meta-analysis to appraise the efficacy and safety of tanezumab for patients with knee OA.

Methods

We systematically searched randomized controlled trials from PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials (CENTRAL). The primary outcomes were mean change in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain, the WOMAC physical function and patient's global assessment (PGA). Outcomes were reported as the standard mean difference (SMD) or relative risk (RR) with 95% confidence interval (CI). We assessed the pooled data using a random-effects model.

Results

Of the identified studies, four we

SUBMITTER: Kan SL 

PROVIDER: S-EPMC4905652 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature