Fecal Microbiota Transplantation for Ulcerative Colitis: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Fecal microbiota transplantation (FMT) has been recognized as a novel treatment for ulcerative colitis (UC). However, its efficacy and safety remain unclear.

Objective

We conducted this systematic review to assess the efficacy and safety of FMT in UC.

Data sources

PubMed, EMBASE, Cochrane Central, Web of Science Core Collection, and three other Chinese databases were searched for reports of FMT in UC with clear outcomes.

Data extraction and synthesis

We estimated pooled rates [with 95% confidence interval (CI)] of clinical remission among 15 cohort studies and clinical response among 16 cohort studies.

Results

Twenty five studies (2 randomized controlled trials, 15 cohort studies, and 8 case studies) with 234 UC patients were included. Overall

SUBMITTER: Shi Y 

PROVIDER: S-EPMC4905678 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature