Effect of Calorie Restriction on Mood, Quality of Life, Sleep, and Sexual Function in Healthy Nonobese Adults: The CALERIE 2 Randomized Clinical Trial.

ABSTRACT:

Importance

Calorie restriction (CR) increases longevity in many species and reduces risk factors for chronic diseases. In humans, CR may improve health span, yet concerns remain about potential negative effects of CR.

Objective

To test the effect of CR on mood, quality of life (QOL), sleep, and sexual function in healthy nonobese adults.

Design, setting, and participants

A multisite randomized clinical trial (Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy Phase 2 [CALERIE 2]) was conducted at 3 academic research institutions. Adult men and women (N = 220) with body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) of 22.0 to 28.0 were randomized to 2 years of 25% CR or an ad libitum (AL) control group i

SUBMITTER: Martin CK 

PROVIDER: S-EPMC4905696 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature