Association Between Genetic Traits for Immune-Mediated Diseases and Alzheimer Disease.

ABSTRACT:

Importance

Late-onset Alzheimer disease (AD), the most common form of dementia, places a large burden on families and society. Although epidemiological and clinical evidence suggests a relationship between inflammation and AD, their relationship is not well understood and could have implications for treatment and prevention strategies.

Objective

To determine whether a subset of genes involved with increased risk of inflammation are also associated with increased risk for AD.

Design, setting, and participants

In a genetic epidemiology study conducted in July 2015, we systematically investigated genetic overlap between AD (International Genomics of Alzheimer's Project stage 1) and Crohn disease, ulcerative colitis, rheumatoid arthritis, type 1 diabetes, celiac disease,

SUBMITTER: Yokoyama JS 

PROVIDER: S-EPMC4905783 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature