Vaccination evokes gender-dependent protection against tularemia infection in C57BL/6Tac mice.

ABSTRACT: Francisella tularensis (Ft) is a Category A biothreat agent for which there currently is no FDA-approved vaccine. Thus, there is a substantial effort underway to develop an effective tularemia vaccine. While it is well established that gender can significantly impact susceptibility to primary infection, the impact of gender on vaccine efficacy is not well established. Thus, development of a successful vaccine against tularemia will require an understanding of the impact gender has on vaccine-induced protection against this organism. In this study, a role for gender in vaccine-induced protection following Ft challenge is identified for the first time. In the present study, mucosal vaccination with inactivated Ft (iFt) LVS elicited gender-based protection in C57BL/6Tac mice against respirato

SUBMITTER: Sunagar R 

PROVIDER: S-EPMC4905791 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature