Resting-state functional connectivity of the human habenula in healthy individuals: Associations with subclinical depression.

ABSTRACT:

Introduction

The habenula (Hb) is postulated to play a critical role in reward and aversion processing across species, including humans, and has been increasingly implicated in depression. However, technical constraints have limited in vivo investigation of the human Hb, and its function remains poorly characterized. We sought to overcome these challenges by examining the whole-brain resting-state functional connectivity of the Hb and its possible relationship to depressive symptomatology using the high-resolution WU-Minn Human Connectome Project (HCP) dataset.

Methods

Anatomical and resting-state functional MRI data from 50 healthy subjects with low or high subclinical depression scores (n = 25 each) were analyzed. Using novel semi-automated segmentation and optimization te

SUBMITTER: Ely BA 

PROVIDER: S-EPMC4905808 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature