Doubt in the Insula: Risk Processing in Obsessive-Compulsive Disorder.

ABSTRACT: Extensive cleaning or checking of patients with obsessive-compulsive disorder (OCD) are often interpreted as strategies to avoid harm and as an expression of the widespread belief that OCD patients are more risk-averse. However, despite its clinical significance, the neural basis of risk attitude in OCD is unknown. Here, we investigated neural activity during risk processing using functional magnetic resonance imaging and simultaneously assessed risk attitude using a separate behavioral paradigm in OCD patients with different symptoms versus healthy controls (HCs). We found opposite insula responses to high versus low risk in OCD patients compared to HCs: a positive correlation between insula activity and risk-aversion in patients versus a negative correlation in controls. Although OCD pat

SUBMITTER: Luigjes J 

PROVIDER: S-EPMC4905944 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature