Multitarget Multiscale Simulation for Pharmacological Treatment of Dystonia in Motor Cortex.

ABSTRACT: A large number of physiomic pathologies can produce hyperexcitability in cortex. Depending on severity, cortical hyperexcitability may manifest clinically as a hyperkinetic movement disorder or as epilpesy. We focus here on dystonia, a movement disorder that produces involuntary muscle contractions and involves pathology in multiple brain areas including basal ganglia, thalamus, cerebellum, and sensory and motor cortices. Most research in dystonia has focused on basal ganglia, while much pharmacological treatment is provided directly at muscles to prevent contraction. Motor cortex is another potential target for therapy that exhibits pathological dynamics in dystonia, including heightened activity and altered beta oscillations. We developed a multiscale model of primary motor cortex, rangi

SUBMITTER: Neymotin SA 

PROVIDER: S-EPMC4906029 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature