A Novel Peptide Binding Prediction Approach for HLA-DR Molecule Based on Sequence and Structural Information.

ABSTRACT: MHC molecule plays a key role in immunology, and the molecule binding reaction with peptide is an important prerequisite for T cell immunity induced. MHC II molecules do not have conserved residues, so they appear as open grooves. As a consequence, this will increase the difficulty in predicting MHC II molecules binding peptides. In this paper, we aim to propose a novel prediction method for MHC II molecules binding peptides. First, we calculate sequence similarity and structural similarity between different MHC II molecules. Then, we reorder pseudosequences according to descending similarity values and use a weight calculation formula to calculate new pocket profiles. Finally, we use three scoring functions to predict binding cores and evaluate the accuracy of prediction to judge performa

SUBMITTER: Li Z 

PROVIDER: S-EPMC4906198 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature