Correlation among DNA Linker Length, Linker Histone Concentration, and Histone Tails in Chromatin.

ABSTRACT: Eukaryotic cells condense their genetic material in the nucleus in the form of chromatin, a macromolecular complex made of DNA and multiple proteins. The structure of chromatin is intimately connected to the regulation of all eukaryotic organisms, from amoebas to humans, but its organization remains largely unknown. The nucleosome repeat length (NRL) and the concentration of linker histones (ρLH) are two structural parameters that vary among cell types and cell cycles; the NRL is the number of DNA basepairs wound around each nucleosome core plus the number of basepairs linking successive nucleosomes. Recent studies have found a linear empirical relationship between the variation of these two properties for different cells, but its underlying mechanism remains elusive. Here we apply our est

SUBMITTER: Luque A 

PROVIDER: S-EPMC4906253 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature